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IB6 recognizes the human CD38 antigen, a single-chain type II transmembrane glycoprotein with enzymatic activity. It is present on the majority of hematopoietic cells, prevalent during early differentiation and activation processes. Terminally differentiated B cells (plasma cells) express CD38 brightly. Furthermore, CD38 is constitutively expressed in several tissues, for example brain, muscle, and kidney.
Miltenyi Biotec B.V. & Co. KG
170-081-002
In Commercial Distribution
- 04049934134579 ()
- Assay development analyte-specific reagent IVD
REA103 recognizes human CD185, which is a 42 kDa G-protein-coupled chemokine receptor and is also known as CXCR5, monocyte-derived receptor 15 (MDR15), or Burkitt lymphoma receptor-1 (BLR1). BLR-1 was originally identified on cells of Burkitt lymphoma and B cells. B cell attracting chemokine 1 (BCA-1), also known as B-lymphocyte chemoattractant (BLC) or CXCL13, is the ligand of CD185. It is further expressed on central memory CD4 T cells, T follicular helper cells, and on a migratory population of skin-derived dendritic cells. Additional information: Clone REA103 displays negligible binding to Fc receptors.
Miltenyi Biotec B.V. & Co. KG
170-081-004
In Commercial Distribution
- 04049934134555 ()
- Assay development analyte-specific reagent IVD
BW242/412 recognizes the human alpha/beta T cell receptor (TCR). The T cell receptor (TCR) is a heterodimer composed of two transmembrane glycoprotein chains, alpha and beta. Both chains are members of the Ig superfamily and consist of a constant and a polymorphic variable region. The variable region of the TCRalpha/beta is involved in recognition of antigenic peptides presented by the MHC complex of antigen-presenting cells. The Anti-TCRalpha/beta antibody, BW242/412, recognizes a common determinant of the TCRalpha/beta-CD3 complex.
Miltenyi Biotec B.V. & Co. KG
170-081-005
In Commercial Distribution
- 04049934134548 ()
- Assay development analyte-specific reagent IVD
The antibody VIT4 is a monoclonal murine IgG2a antibody, which recognizes the human CD4 antigen which is highly expressed on human T helper cells and thymocytes, and at lower levels on monocytes and dendritic cells. It is responsible for the recognition of the MHC Class II antigen.
Miltenyi Biotec B.V. & Co. KG
170-081-007
In Commercial Distribution
- 04049934134524 ()
- Assay development analyte-specific reagent IVD
LT20 recognizes the CD20 antigen, a non-glycosylated transmembrane protein of 33–37 kDa that is expressed on B lineage cells from the pre-B cell stage to the B cell lymphoblast stage. The antigen is further expressed on most malignant B cells. CD20 is not found on early B cell progenitors or plasma cells. Oligomers of CD20 form a Ca2+ channel and might function in the regulation of local responses during B cell activation.
Miltenyi Biotec B.V. & Co. KG
170-081-009
In Commercial Distribution
- 04049934134500 ()
- Assay development analyte-specific reagent IVD
M-T271 recognizes CD27, a member of the tumor necrosis factor receptor family. CD27 is expressed at differing levels on memory B cells, a fraction of plasma cells, and on naive and memory T cells, but is not expressed on naive B cells or effector T cells. It is also expressed on NK cells. CD27 therefore represents a useful marker to distinguish certain T and B cell subsets from each other.
Miltenyi Biotec B.V. & Co. KG
170-081-011
In Commercial Distribution
- 04049934134487 ()
- Assay development analyte-specific reagent IVD
5B1 recognizes the human CD45 antigen, a tyrosine phosphatase also known as the leukocyte common antigen (LCA). The CD45 molecule is required for T and B cell activation and is expressed in at least five isoforms depending on the differentiation status of the cell. The CD45 antibody recognizes a common epitope of all CD45 isoforms.
Miltenyi Biotec B.V. & Co. KG
170-081-012
In Commercial Distribution
- 04049934134470 ()
- Assay development analyte-specific reagent IVD
5B1 recognizes the human CD45 antigen, a tyrosine phosphatase also known as the leukocyte common antigen (LCA). The CD45 molecule is required for T and B cell activation and is expressed in at least five isoforms depending on the differentiation status of the cell. The CD45 antibody recognizes a common epitope of all CD45 isoforms.
Miltenyi Biotec B.V. & Co. KG
170-081-013
In Commercial Distribution
- 04049934134463 ()
- Assay development analyte-specific reagent IVD
REA196 recognizes the human CD56 antigen, a glycoprotein of the Ig-superfamily, also known as neural cell adhesion molecule (NCAM), which is expressed in blood on practically all resting and activated NK cells and on a minor subset of CD3+ T cells. CD56 is also expressed in brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal-derived tumors, myelomas, and myeloid leukemias also express CD56. Additional information: Clone REA196 displays negligible binding to Fc receptors.
Miltenyi Biotec B.V. & Co. KG
170-081-014
In Commercial Distribution
- 04049934134456 ()
- Assay development analyte-specific reagent IVD
A3C6E2 recognizes human CD117, also known as c-kit or SCF receptor. It is a 145 kDa receptor tyrosine kinase that is involved in stem cell signaling, activation, and proliferation. The CD117 antigen is expressed on about 1–3% of mononuclear cells from peripheral blood mononuclear cells (PBMCs) or cord blood, and on up to 10% of bone marrow cells. CD117 is further expressed on basophils, myeloid dendritic cells, TCRa/b+ T cells, CD19+ B cells, and CD56+ NK cells, as well as on mast cells, melanocytes, and AML (acute myeloid leukemia) blasts.
Miltenyi Biotec B.V. & Co. KG
170-081-015
In Commercial Distribution
- 04049934134449 ()
- Assay development analyte-specific reagent IVD