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VIMC6 recognizes the human CD15 antigen which is expressed on human myelomonocytic cells. It is present on neutrophils, eosinophils, and some monocytes, masked on basophils but not on lymphocytes. The antigen is also expressed on Hodgkin/Reed-Sternberg cells. The CD15 antibody recognizes the carbohydrate structure 3-fucosyl-N-acetyl-lactosamine. This structure is also known as stage specific embryonic antigen 1 (SSEA-1) and a common surface marker for pluripotency on mouse ES and iPS cells. On human cells in contrast, SSEA-1 is expressed only on early differentiating cells. The CD15 antibody recognizes the SSEA-1 antigen in both species. For applications in ES and iPS research, the dilution recommended in the data sheet may need adjustment.
Miltenyi Biotec B.V. & Co. KG
170-081-049
In Commercial Distribution
- 04049934134104 ()
- Assay development analyte-specific reagent IVD
4E3 recognizes the human CD25 antigen, a 55 kDa glycoprotein also known as the low-affinity interleukin-2 receptor alpha chain (IL-2Rα). CD25 is expressed on activated T and B cells, on macrophages, and on a subset of non-activated CD4+ regulatory T cells. The CD25 antigen contains three epitope regions called A, B, and C. This CD25 antibody recognizes epitope region B.
Miltenyi Biotec B.V. & Co. KG
170-081-050
In Commercial Distribution
- 04049934134098 ()
- Assay development analyte-specific reagent IVD
M-T271 recognizes CD27, a member of the tumor necrosis factor receptor family. CD27 is expressed at differing levels on memory B cells, a fraction of plasma cells, and on naive and memory T cells, but is not expressed on naive B cells or effector T cells. It is also expressed on NK cells. CD27 therefore represents a useful marker to distinguish certain T and B cell subsets from each other.
Miltenyi Biotec B.V. & Co. KG
170-081-051
In Commercial Distribution
- 04049934134081 ()
- Assay development analyte-specific reagent IVD
REA414 recognizes the human CD66c antigen, a glycosylphosphatidylinositol (GPI) linked protein, which is also known as carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6). Within the hematopoietic system, CD66c expression is limited to granulocytes and its precursors, where it serves homotypic and heterotypic adhesion, Ca2+ mediated signaling, and is markedly upregulated from intracellular stores after activation. It is also found in epithelia of various organs. CD66c overexpression is found in a wide variety of epithelial cancer types such as lung, breast, colorectal, and hepatocellular carcinomas.
Additional information: Clone REA414 displays negligible binding to Fc receptors.
Miltenyi Biotec B.V. & Co. KG
170-081-052
In Commercial Distribution
- 04049934134074 ()
- Assay development analyte-specific reagent IVD
The monoclonal antibody UP-H2 reacts with human CD300e, also known as IREM-2, LMIR6, or CMRF35-A5. This 34 kDa activating receptor of the immunoglobulin superfamily is expressed on mature myeloid dendritic cells and monocytes and is down-regulated on immature dendritic cells. CD300e interacts with DAP-12, which mediates activating signals. It is reported that the alloreactive response of naive T cells is enhanced by IREM-2 activation of mDCs.
Miltenyi Biotec B.V. & Co. KG
170-081-053
In Commercial Distribution
- 04049934134067 ()
- Assay development analyte-specific reagent IVD
REA613 recognizes the human CD3 antigen, a single-pass type I membrane protein, also known as Leu4. CD3 is present on mature human T cells, thymocytes, a subset of NK cells, and on Purkinje cells in cerebellum. It is associated with the T cell receptor (TCR) and is responsible for its signal transduction. The CD3 antigen is a complex of five invariable chains: gamma, delta, epsilon, zeta and eta. The epitope recognized by the antibody is located on the epsilon-chain of the CD3 complex. Additional information: Clone REA613 displays negligible binding to Fc receptors.
Miltenyi Biotec B.V. & Co. KG
170-081-054
In Commercial Distribution
- 04049934134050 ()
- Assay development analyte-specific reagent IVD
REA613 recognizes the human CD3 antigen, a single-pass type I membrane protein, also known as Leu4. CD3 is present on mature human T cells, thymocytes, a subset of NK cells, and on Purkinje cells in cerebellum. It is associated with the T cell receptor (TCR) and is responsible for its signal transduction. The CD3 antigen is a complex of five invariable chains: gamma, delta, epsilon, zeta, and eta. The epitope recognized by the antibody is located on the epsilon-chain of the CD3 complex. Additional information: Clone REA613 displays negligible binding to Fc receptors.
Miltenyi Biotec B.V. & Co. KG
170-081-055
In Commercial Distribution
- 04049934134043 ()
- Assay development analyte-specific reagent IVD
VIT4 recognizes the human CD4 antigen which is highly expressed on human T helper cells and thymocytes, and at lower levels on monocytes and dendritic cells. It is responsible for the recognition of the MHC Class II antigen.
Miltenyi Biotec B.V. & Co. KG
170-081-056
In Commercial Distribution
- 04049934134036 ()
- Assay development analyte-specific reagent IVD
LT19 recognizes the human CD19 antigen, a type-I transmembrane glycoprotein of 95 kDa that belongs to the immunoglobulin superfamily. CD19 is expressed on B cells throughout most stages of B cell differentiation, though its expression is down-regulated during their terminal differentiation to plasma cells. Expression of CD19 is also found in the majority of B cell–derived malignancies. CD19 is further present on follicular dendritic cells. On B cells, CD19 associates with CD21, CD81, and CD225 (Leu-13) forming a signal transduction complex.
Miltenyi Biotec B.V. & Co. KG
170-081-057
In Commercial Distribution
- 04049934134029 ()
- Assay development analyte-specific reagent IVD
LT20 recognizes the CD20 antigen, a non-glycosylated transmembrane protein of 33–37 kDa that is expressed on B lineage cells from the pre-B cell stage to the B cell lymphoblast stage. The antigen is further expressed on most malignant B cells. CD20 is not found on early B cell progenitors or plasma cells. Oligomers of CD20 form a Ca2+ channel and might function in the regulation of local responses during B cell activation.
Miltenyi Biotec B.V. & Co. KG
170-081-058
In Commercial Distribution
- 04049934134012 ()
- Assay development analyte-specific reagent IVD