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Clone REA423 recognizes the human CD16 antigen, a single-pass type I membrane protein which is also known as low affinity immunoglobulin gamma Fc region receptor III (FcRIII). CD16 is a 50–80 kDa glycoprotein that is expressed in two different isoforms. The transmembrane form is found on human NK cells, macrophages, and mast cells, while the glycosylphosphatidylinositol (GPI)-linked form is present on neutrophils. The human CD16 antigen is a low-affinity receptor for aggregated IgG. The transmembrane form plays a role in signal transduction, NK cell activation, and antibody-dependent cellular cytotoxicity. Clone REA423 recognizes both the extracellular domain of the transmembrane form as well as the GPI-linked form of the human CD16 antigen. CD16 is expressed on the majority of rhesus monkey NK cells and on a subset of monocytes but not on granulocytes. Additional information: Clone REA423 displays negligible binding to Fc receptors.
Miltenyi Biotec B.V. & Co. KG
170-081-065
In Commercial Distribution
- 04049934133947 ()
- Assay development analyte-specific reagent IVD
REA675 recognizes the human CD19 antigen, a type I transmembrane glycoprotein of 95 kDa that belongs to the immunoglobulin superfamily. CD19 is expressed on B cells throughout most stages of B cell differentiation, though its expression is down-regulated during their terminal differentiation to plasma cells. Expression of CD19 is also found in the majority of B cell–derived malignancies. CD19 is further present on follicular dendritic cells. On B cells, CD19 associates with CD21, CD81, and CD225 (Leu-13) forming a signal transduction complex. Additional information: Clone REA675 displays negligible binding to Fc receptors.
Miltenyi Biotec B.V. & Co. KG
170-081-066
In Commercial Distribution
- 04049934133930 ()
- Assay development analyte-specific reagent IVD
REA675 recognizes the human CD19 antigen, a type I transmembrane glycoprotein of 95 kDa that belongs to the immunoglobulin superfamily. CD19 is expressed on B cells throughout most stages of B cell differentiation, though its expression is down-regulated during their terminal differentiation to plasma cells. Expression of CD19 is also found in the majority of B cell–derived malignancies. CD19 is further present on follicular dendritic cells. On B cells, CD19 associates with CD21, CD81, and CD225 (Leu-13) forming a signal transduction complex. Additional information: Clone REA675 displays negligible binding to Fc receptors.
Miltenyi Biotec B.V. & Co. KG
170-081-067
In Commercial Distribution
- 04049934133923 ()
- Assay development analyte-specific reagent IVD
Clone REA671 recognizes the human CD38 antigen, a single-chain type II transmembrane glycoprotein with enzymatic activity. It is present on the majority of hematopoietic cells, prevalent during early differentiation and activation processes. Terminally differentiated B cells (plasma cells) express CD38 brightly. Furthermore, CD38 is constitutively expressed in several tissues, for example, brain, muscle, and kidney. CD38, a disease marker for human leukemias and myelomas, plays a role in the pathogenesis and outcome of human immunodeficiency virus infection and chronic lymphocytic leukemia, and controls insulin release and also the development of diabetes. Furthermore, it catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose which is essential for the regulation of intracellular Ca2+.
Additional information: Clone REA671 displays negligible binding to Fc receptors.
Miltenyi Biotec B.V. & Co. KG
170-081-068
In Commercial Distribution
- 04049934133916 ()
- Assay development analyte-specific reagent IVD
REA652 recognizes the human alpha/beta T cell receptor (TCR). The T cell receptor is a heterodimer composed of two transmembrane glycoprotein chains, alpha and beta. In 95% of T cells the TCR consists of an alpha and beta chain, whereas in 5% of T cells it has gamma and delta chains. Alpha and beta chains are members of the Ig superfamily and consist of a constant and a polymorphic variable region. The variable region of the TCRalpha/beta is involved in recognition of antigenic peptides presented by the MHC complex of antigen-presenting cells. Additional information: Clone REA652 displays negligible binding to Fc receptors.
Miltenyi Biotec B.V. & Co. KG
170-081-069
In Commercial Distribution
- 04049934133909 ()
- Assay development analyte-specific reagent IVD
REA652 recognizes the human alpha/beta T cell receptor (TCR). The T cell receptor is a heterodimer composed of two transmembrane glycoprotein chains, alpha and beta. In 95% of T cells the TCR consists of an alpha and beta chain, whereas in 5% of T cells it has gamma and delta chains. Alpha and beta chains are members of the Ig superfamily and consist of a constant and a polymorphic variable region. The variable region of the TCRalpha/beta is involved in recognition of antigenic peptides presented by the MHC complex of antigen-presenting cells. Additional information: Clone REA652 displays negligible binding to Fc receptors.
Miltenyi Biotec B.V. & Co. KG
170-081-070
In Commercial Distribution
- 04049934133893 ()
- Assay development analyte-specific reagent IVD
11F2 recognizes the human gamma/delta T cell receptor (TCR). The T cell receptor is a heterodimeric glycoprotein associated with the CD3 antigen. The TCR consists of a alpha and a beta chain (TCRa/b) or a gamma and a delta chain (TCRg/d). Clone 11F2 reacts with a framework epitope of the gamma/delta T cell–receptor. The gamma and delta TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. The gamma chain forms either disulfide-linked or non-disulfide-linked heterodimers with the delta-subunit. The gamma/delta T cell–receptor is present on a subset of T lymphocytes in peripheral blood, intestinal epithelium, lymph node, thymus, and spleen. TCR gamma/delta is involved in the recognition of certain bacterial, self-CD1 molecule, and tumor antigens bound to MHC class I. Gamma/delta T cells are mainly CD4 negative and CD8 negative. T cells expressing the gamma/delta TCR have been shown to play a role in oral tolerance, innate immune response for some tumor cells, and autoimmune disease. Antigen presentation by gamma/delta T cells has been reported.
Miltenyi Biotec B.V. & Co. KG
170-081-071
In Commercial Distribution
- 04049934133886 ()
- Assay development analyte-specific reagent IVD
REA599 recognizes the human CD14 antigen. CD14 is part of the functional heteromeric LPS receptor complex comprised of at least CD14, TLR4, and MD-2. It up-regulates cell surface molecules, including adhesion molecules. CD14 is strongly expressed on most human monocytes and macrophages in peripheral blood, other bodily fluids, and in various tissues, such as lymph nodes and spleen. CD14 is weakly expressed on subpopulations of human neutrophils and myeloid dendritic cells. Additional information: Clone REA599 displays negligible binding to Fc receptors.
Miltenyi Biotec B.V. & Co. KG
170-081-072
In Commercial Distribution
- 04049934133879 ()
- Assay development analyte-specific reagent IVD
BW135/80 recognizes the human CD8 antigen which is strongly expressed on human cytotoxic T cells and thymocytes, and is also expressed on a subset of NK cells. The CD8 antigen is a disulfide-linked dimer that exists either as a CD8alpha homodimer or as a CD8alpha/beta heterodimer. CD8 acts as a coreceptor for the T cell receptor and binds to the MHC Class I molecule. The CD8 antibody recognizes the alpha-subunit of the antigen.
Miltenyi Biotec B.V. & Co. KG
170-081-073
In Commercial Distribution
- 04049934133862 ()
- Assay development analyte-specific reagent IVD
REA780 recognizes the human CD20 antigen, a non-glycosylated transmembrane protein of 33–37 kDa that is expressed on B lineage cells from the pre–B cell stage to the B cell lymphoblast stage. The antigen is further expressed on most malignant B cells. CD20 is not found on early B cell progenitors or plasma cells. Oligomers of CD20 form a Ca2+ channel and might function in the regulation of local responses during B cell activation.
Additional information: Clone REA780 displays negligible binding to Fc receptors.
Miltenyi Biotec B.V. & Co. KG
170-081-074
In Commercial Distribution
- 04049934133855 ()
- Assay development analyte-specific reagent IVD